Structure-Activity relationship studies of illudins: analogues possessing a spiro-cyclobutane ring

TC McMorris, Q Cong, MJ Kelner

文献索引：McMorris, Trevor C.; Cong, Qiang; Kelner, Michael J. Journal of Organic Chemistry, 2003 , vol. 68, # 25 p. 9648 - 9653

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被引用次数: 19

摘要

Bicyclic and tricyclic analogues of anticancer sesquiterpene illudin S have been synthesized. These contain a spiro-cyclobutane instead of spiro-cyclopropane structure. The cytotoxicity of the former is less than that of the corresponding cyclopropane-containing compounds.