Synthesis and antiarrhythmic activity of novel 3-alkyl-1-[. omega.-[4-[(alkylsulfonyl) amino] phenyl]-. omega.-hydroxyalkyl]-1H-imidazolium salts and related …

R Lis, TK Morgan Jr, RJ DeVita, DD Davey…

文献索引：Lis, Randall; Morgan, Thomas K.; DeVita, Robert J.; Davey, David D.; Lumma, William C.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 696 - 704

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被引用次数: 18

摘要

Novel 3-alkyl-1-[w-[4-[(alkylsulfonyl) amino] phenyl]-w-hydroxyalkyl]-lH-imidazolium salts were synthesized and investigated for their class I11 electrophysiological activity on isolated canine cardiac Purkinje fibers and ventricular muscle tissue. Structure-activity relationships are discussed for a series of 25 compounds. Compound 3, 1-[2-hydroxy-2-[4- [(methylsulfonyl) amino] phenyl] ethyl]-3-methyl-1H-imidazolium chloride, prolonged the ...