Tetrahedron

Synthese de cetones aliphatiques encombrees: Action des organolithiens sur les dimethyl-4, 4 oxazolines-2. Addition des organometalliques sur les sels de dimethyl- …

C Lion, JE Dubois

文献索引：Lion,C.; Dubois,J.E. Tetrahedron, 1973 , vol. 29, p. 3417 - 3423

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被引用次数: 16

摘要

α, α-Disubstituted ketones result from the reaction of organolithium compounds with substituted 4, 4-dimethyl-2-oxazolines, 4, after hydrolysis of the intermediate enamine. Alkylation of the latter also permits the synthesis of α, α, α-trisubstituted ketones. α, α- Disubstituted ketones have been prepared by addition of organometallic reagents to 4, 4- dimethyl-2-oxazolinium salts, 6. The efficiency of this method has been compared to that ...