Discovery of novel, non-acidic 1, 5-biaryl pyrrole EP 1 receptor antagonists

…, GMP Giblin, P Goldsmith, MP Healy, KS Jandu…

文献索引：Hall, Adrian; Atkinson, Stephen; Brown, Susan H.; Chessell, Iain P.; Chowdhury, Anita; Giblin, Gerard M.P.; Goldsmith, Paul; Healy, Mark P.; Jandu, Karamjit S.; Johnson, Matthew R.; Michel, Anton D.; Naylor, Alan; Sweeting, Jennifer A. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1200 - 1205

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被引用次数: 32

摘要

Replacement of the carboxylic acid group in a series of previously described 1, 5-biaryl pyrrole EP1 receptor antagonists led to the discovery of various novel non-acidic antagonists. Several analogues displayed high binding affinity and high binding efficiency indices.