Biosynthesis of vitamin B1 in yeast. Derivation of the pyrimidine unit from pyridoxine and histidine. Intermediacy of urocanic acid

J Zeidler, BG Sayer, ID Spenser

文献索引：Zeidler, Johannes; Sayer, Brian G; Spenser, Ian D Journal of the American Chemical Society, 2003 , vol. 125, # 43 p. 13094 - 13105

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被引用次数: 45

摘要

Incorporation studies with 13C-, 15N-, and 2H-labeled substrates, followed by NMR analysis, show that the pyrimidine unit of thiamin (Vitamin B1) originates from a C5N fragment, derived from C-2', 2, N, C-6, 5, 5'of pyridoxol (Vitamin B6) and an NCN fragment derived from l-histidine. Urocanic acid serves as an intermediate on the route of the NCN fragment of histidine into the thiamin pyrimidine.