Process development and scale-up of the PPAR agonist NNC 61-4655

…, B Weber, V Weil, SJ Mozer, P Sauerberg

文献索引：Horner et al. Chemische Berichte, 1959 , vol. 92, p. 2088,2093

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被引用次数: 24

摘要

... At some stage in the Wittig−Horner reaction, foaming was observed during the addition of 1 to the deprotonated triethyl ... Other bases, such as KOtBu, NaOH, KOH, K 2 CO 3 , and Et 3 N were tested in THF ... THF was replaced by toluene, and the volume was reduced 100 times. ...