Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis

Y Iwata, M Arisawa, R Hamada, Y Kita…

文献索引：Costantino, Luca; Rastelli, Giulio; Gamberini, M. Cristina; Giovannoni, M. Paola; Piaz, Vittorio Dal; Vianello, Paola; Barlocco, Daniela Journal of Medicinal Chemistry, 1999 , vol. 42, # 11 p. 1894 - 1900

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被引用次数: 63

摘要

... Journal of Medicinal ... School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan, and Institute of Medicinal Molecular Design, 5 ... In the pharmaceutical industry an acceptable lead typically has a dissociation constant of 10 μM or better. ...