Synthesis of three 18 F-labelled cyclooxygenase-2 (COX-2) inhibitors based on a pyrimidine scaffold

…, J Kaur, J Way, A Marshall, M Wuest, F Wuest

文献索引：Tietz, Ole; Sharma, Sai Kiran; Kaur, Jatinder; Way, Jenilee; Marshall, Alison; Wuest, Melinda; Wuest, Frank Organic and Biomolecular Chemistry, 2013 , vol. 11, # 46 p. 8052 - 8064

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被引用次数: 12

摘要

Cyclooxygenase (COX) is the key enzyme within the complex conversion of arachidonic acid into prostaglandins (PGs). Inhibitors of this enzyme represent a particularly promising class of compounds for chemoprevention and cancer therapy. The experimental data on the involvement of COX isoform COX-2 in tumour d