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Synthesis and study of psychotropic and hypotensive properties of new picamilon derivatives

VM Kopelevich, LN Bulanova, IA Grigor'ev…

文献索引:Kopelevich; Bulanova; Grigor'ev; Gorbunov; Sabanov; Adzhienko; Il'in; Perfilova; Tyurenkov; Petrov; Gunar Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 10 p. 536 - 539

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摘要

Picamilon (an original drug synthesized at the "Vi- taminy" Research and Production Association [I]) is an N-ni- cotinoyl derivative of GABA (Ia). Experience gained in the clinical use of this drug shows that it combines pronounced vasodilatation properties with nootropic effects and tranquil- izer activity [2 - 5]. Although the tranquilizer action of pi- camilon is somewhat less pronounced as compared to that of diazepam, the former has the advantages of having no myore- ...