Synthesis and cytotoxic activity of lipophilic sulphonamide derivatives of the benzo [b] thiophene 1, 1-dioxide

…, I Encio, M Migliaccio, MJ Gil, V Martinez-Merino

文献索引：Villar; Encio; Migliaccio; Gil; Martinez-Merino Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 963 - 968

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被引用次数: 72

摘要

In the search of new compounds with antineoplastic activity, we have analysed the effect of several structural modifications on the nucleus 6-benzo [b] thiophenesulphonamide 1, 1- dioxide on its cytotoxic activity on tumour cells. Lipophilic substituents on the sulphonamide group significantly increased the cytoxic activity measured using a panel of human tumour cell lines. Only slight variations on cytotoxicity were obtained when the sulphonamide ...