Abstract A new method for the synthesis of 5-hydroxy-3-pyrrolin-2-ones is reported. Conversion of N-Boc-3-pyrrolin-2-ones into 2-triisopropylsilyloxypyrroles and ensuing oxidation with dimethyldioxirane provides the corresponding N-Boc-5-hydroxy-3-pyrrolin-2- ones in high yields.
[Cuiper, Agnes D.; Kouwijzer, Milou L. C. E.; Grootenhuis, Peter D. J.; Kellogg, Richard M.; Feringa, Ben L. Journal of Organic Chemistry, 1999 , vol. 64, # 26 p. 9529 - 9537]
