A simple synthesis of a new amino acid derivative 5, 6-bis (trimethylsilyl) indanylglycine via cobalt mediated [2+ 2+ 2] cycloaddition strategy is described. Co-trimerization of diyne building block containing amino acid moiety with bis (trimethylsilyl) acetylene in presence of CpCo (CO) 2 catalyst afforded the silylated indane-based α-amino acid (AAA) derivative. Electrophilic aromatic substitution reaction, ipso to the trimethylsilyl group gave highly ...
