The advantages of the “naked carbon skeleton” strategy in the total synthesis of polyoxygenated natural products are demonstrated in the total synthesis of the 18- membered macrolide (+)-aspicilin, 1. This approach employs the easily prepared, nonfunctionalized carbon skeleton of the target molecule, hexadeca-1, 3, 15-triene, 2. All the required stereogenic carbinol centers are then introduced onto this partially unsaturated ...
