Tetrahedron Letters

Phenoxide-mediated Sonogashira coupling of trimethylsilylalkynes and aryliodides: practical synthesis of phenolic-hydroxy-substituted diarylethynes and 1, 4- …

M Shigeta, J Watanabe, G Konishi

文献索引：Shigeta, Masayuki; Watanabe, Junji; Konishi, Gen-Ichi Tetrahedron Letters, 2013 , vol. 54, # 13 p. 1761 - 1764

全文：HTML全文

被引用次数: 5

摘要

We successfully synthesized phenolic-hydroxy-substituted diarylethynes and 1, 4- diarylbutadiynes from trimethylsilylalkynes and aryliodides via silyl-group-migration-induced deprotection of alkynes and the usual Sonogashira coupling. The phenol moiety, which works as a desilylating agent, can be attached to any position in the coupling partner. This improvement for Sonogashira coupling would be highly effective, especially when the ...