Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells

JL Harper, CS Camerini-Otero, AH Li, SA Kim…

文献索引：Harper, Jacquie L.; Camerini-Otero, Carol S.; Li, An-Hu; Kim, Soon-Ai; Jacobson, Kenneth A.; Daly, John W. Biochemical Pharmacology, 2003 , vol. 65, # 3 p. 329 - 338

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被引用次数: 95

摘要

A series of 1, 4-dihydropyridines (DHPs) were investigated as inhibitors of capacitative calcium influx through store-operated calcium (SOC) channels. Such channels activate after ATP-elicited release of inositol trisphosphate (IP3)-sensitive calcium stores in leukemia HL- 60 cells. The most potent DHPs were those containing a 4-phenyl group with an electron- withdrawing substituent, such as m-or p-nitro-or m-trifluoromethyl (ic50 values: 3–6μM). ...