Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative

Y Yoshida, K Matsuda, H Sasaki, Y Matsumoto…

文献索引：Yoshida, Yoshiki; Matsuda, Keiji; Sasaki, Hiroshi; Matsumoto, Yoshimi; Matsumoto, Satoru; Takasugi, Hisashi Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 21 p. 3123 - 3126

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被引用次数: 7

摘要

The synthesis and anti-Helicobacter pylori activity of a novel cephem derivative FR182024 (1) are described. FR182024 having a (5-methyl-1, 3, 4-thiadiazol-2-yl)-thio moiety at the 3- position and a phenylacetamido at the 7-position was found to have extremely potent in vitro anti-H. pylori activity, superior therapeutic efficacy to AMPC and CAM, and low potential for causing diarrhea.