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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis and properties of some 13??cis and all??trans??retinamides

…, JL Frye, CA O'Dell, MC Thorpe, MC Kirk…

文献索引：Shealy; Frye; O'Dell; Thorpe; Kirk; Coburn Jr.; Sporn Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 6 p. 745 - 751

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被引用次数: 23

摘要

Abstract Several 13-cis-retinamides were synthesized from 13-cis-retinoic acid via either 13- cis-retinoyl chloride or 13-cis-1-retinoylimidazole. All-trans-retinoylglycine was prepared from all-trans-retinoyl chloride and ethyl glycinate. Detailed procedures were developed for the preparation of other all-trans-retinamides on a large scale for studies of the chemoprevention of cancer.

维生素A酸；视黄酸结构式

维生素A酸；视黄酸

~%

vitamin A acid ethylamide结构式

vitamin A acid ...

Retinoyl chloride结构式

Retinoyl chloride

乙胺结构式

~%

vitamin A acid ethylamide结构式

vitamin A acid ...

维生素A酸；视黄酸结构式

维生素A酸；视黄酸

~%

[4-[[(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl]amino]phenyl] 2,2-dimethylpropanoate结构式

[4-[[(2Z,4E,6E,...

Retinoyl chloride结构式

Retinoyl chloride

~%

[4-[[(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl]amino]phenyl] 2,2-dimethylpropanoate结构式

[4-[[(2Z,4E,6E,...

特戊酰氯结构式

芬维A胺结构式

~%

[4-[[(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl]amino]phenyl] 2,2-dimethylpropanoate结构式

[4-[[(2Z,4E,6E,...

维生素A酸；视黄酸结构式

维生素A酸；视黄酸

~%

N-(2-hydroxyethyl)retinamide结构式

N-(2-hydroxyeth...

Retinoyl chloride结构式

Retinoyl chloride

2-氨基乙醇结构式

~%

N-(2-hydroxyethyl)retinamide结构式

N-(2-hydroxyeth...

维生素A酸；视黄酸结构式

维生素A酸；视黄酸

~%

(2Z,4E,6Z,8Z)-N-butyl-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenamide结构式

(2Z,4E,6Z,8Z)-N...

Retinoyl chloride结构式

Retinoyl chloride

正丁胺结构式

~%

(2Z,4E,6Z,8Z)-N-butyl-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenamide结构式

(2Z,4E,6Z,8Z)-N...

4-氨基-1-丁醇结构式

4-氨基-1-丁醇

异维A酸结构式

~61%

(2Z,4E,6E,8E)-N-(4-hydroxybutyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide结构式

(2Z,4E,6E,8E)-N...

乙胺结构式

13-cis-retinoyl chloride结构式

13-cis-retinoyl...

~75%

(2Z,4E,6E,8E)-N-ethyl-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide结构式

(2Z,4E,6E,8E)-N...

异维A酸结构式

~%

(2Z,4E,6E,8E)-N-ethyl-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide结构式

(2Z,4E,6E,8E)-N...

4-氨基-1-丁醇结构式

4-氨基-1-丁醇

维生素A酸；视黄酸结构式

维生素A酸；视黄酸

~73%

(2E,4E,6E,8E)-N-(4-hydroxybutyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide结构式

(2E,4E,6E,8E)-N...

对氨基苯酚结构式

对氨基苯酚

13-cis-retinoyl chloride结构式

13-cis-retinoyl...

~82%

13-顺式芬尼替尼结构式

13-顺式芬尼替尼

异维A酸结构式

~%

13-顺式芬尼替尼结构式

13-顺式芬尼替尼

维生素A酸；视黄酸结构式

维生素A酸；视黄酸

3-氨基丙醇结构式

~64%

(7cis,9cis,13cis)-15-[(3-Hydroxypropyl)amino]retinal结构式

(7cis,9cis,13ci...