Structure-based design of sulfonamide-substituted non-peptidic HIV protease inhibitors

…, MN Janakiraman, LA Dolak, JP McGrath

文献索引：Skulnick; Johnson; Howe; Tomich; Chong; Watenpaugh; Janakiraman; Dolak; McGrath; Lynn; Horng; Hinshaw; Zipp; Ruwart; Schwende; Zhong; Padbury; Dalga; Shiou; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 26 p. 4968 - 4971

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被引用次数: 59

摘要

The rapid and alarming spread of acquired immune deficiency syndrome (AIDS) has sparked an intense worldwide search for drugs to combat the causative agent of this disease, human immunodeficiency virus (HIV). The HIV protease enzyme is a particularly attractive target in this regard since it plays a key role in viral maturati0n. l Although a number of interesting compounds are in development, they are primarily peptide based ...

Structure-based design of nonpeptidic HIV protease inhibitor...

[Skulnick, Harvey I.; Johnson, Paul D.; Aristoff, Paul A.; Morris, Jeanette K.; Lovasz, Kristine D.; Howe, W. Jeffrey; Watenpaugh, Keith D.; Janakiraman, Musiri N.; Anderson, David J.; Reischer, Robert J.; Schwartz, Theresa M.; Banitt, Lee S.; Tomich, Paul K.; Lynn, Janet C.; Horng, Miao-Miao; Chong, Kong-Teck; Hinshaw, Roger R.; Dolak, Lester A.; Seest, Eric P.; Schwende, Francis J.; Rush, Bob D.; Howard, Gina M.; Toth, Lisa N.; Wilkinson, Karen R.; Kakuk, Thomas J.; Johnson, Carol W.; Cole, Serena L.; Zaya, Renee M.; Zipp, Gail L.; Possert, Peggy L.; Dalga, Robert J.; Zhong, Wei-Zhu; Williams, Marta G.; Romines, Karen R. Journal of Medicinal Chemistry, 1997 , vol. 40, # 7 p. 1149 - 1164]