Synthesis and biological evaluation of monoindolyl and indolocarbazolyl oxazolones and imidazolones.

…, M OLLIER, D SEVERE, JF RIOU, H CREVEL…

文献索引：Pereira, Elisabete Rodrigues; Prudhomme, Michelle; Sancelme, Martine; Ollier, Monique; Severe, Daniele; Riou, Jean Francois; Crevel, Henri; Savineau, Jean Pierre; Fabbro, Doriano; Meyer, Thomas Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 4 p. 733 - 736

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被引用次数: 12

摘要

Eight compounds structurally related to protein kinase C inhibitor MDL 27032 and substituted with indole moieties were synthesized. Their activities towards protein kinase C (PKC) and protein kinase A (PKA) were determined. Their effect on PKC-mediated contraction of rat tracheal smooth muscle, their antiproliferative activity on two murine tumor cell lines, melanoma B16 and leukemia P388 and their antimicrobial activity on a gram- ...