Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 4-{4-[2-(4-(2-substitutedquinoxalin-3-yl) piperazin-1-yl) ethyl] phenyl} thiazoles as …
Abstract A series of 4-{4-[2-(4-(2-substitutedquinoxalin-3-yl) piperazin-1-yl) ethyl] phenyl} thiazoles were synthesized in an effort to prepare novel atypical antipsychotic agents. The compounds were designed, synthesized, and characterized by spectral data (IR, 1 H NMR, and MS) and the purity was ascertained by microanalysis. The D 2 and 5-HT 2A affinity of the synthesized compounds was screened in vitro by radioligand displacement assays on ...
