Bis??Sulfamyl Imines: Potent Substrates for Asymmetric Additions of Arylboroxines under Rhodium Catalysis

R Crampton, S Woodward, M Fox

文献索引：Crampton, Rosemary; Woodward, Simon; Fox, Martin Advanced Synthesis and Catalysis, 2011 , vol. 353, # 6 p. 903 - 906

全文：HTML全文

被引用次数: 14

摘要

Abstract Bis-sulfamyl imines are shown to be potentially ideal substrates for rhodium- catalysed asymmetric additions of arylboron nucleophiles as they show:(i) near perfect enantioselectivities (11 examples, 98–99+% ee),(ii) good to excellent diastereoselectivities (10–32: 1 rac: meso), and (iii) high functional group tolerance in removal of the low molecular weight protecting group via mild heating in aqueous pyridine.