Tetrahedron letters

Strategies for protecting and manipulating triazine derivatives

E Hollink, EE Simanek, DE Bergbreiter

文献索引：Hollink, Emily; Simanek, Eric E.; Bergbreiter, David E. Tetrahedron Letters, 2005 , vol. 46, # 12 p. 2005 - 2008

全文：HTML全文

被引用次数: 27

摘要

Aminotriazine derivatives are available in two steps by treating chlorotriazines with acid- labile benzylic amines including triphenylmethylamine, diphenylmethylamine, and 2, 4- dimethoxybenzyl-amine (Dmb-amine), followed by deprotection using trifluoroacetic acid. This high yielding (85–99%) protocol is a milder alternative to the traditional method that uses ammonia and high temperature as a route to aminotriazine derivatives. The ...