Synthesis of 1??Amino??1H??indole??3??carboxylates by Copper (I)??Catalyzed Intramolecular Amination of Aryl Bromides

…, M Yurovskaya, A Karchava

文献索引：Melkonyan, Ferdinand S.; Karchava, Alexander V.; Yurovskaya, Marina A. Journal of Organic Chemistry, 2008 , vol. 73, # 11 p. 4275 - 4278

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被引用次数: 18

摘要

Abstract A simple route to various N-substituted 1-amino-1H-indole-3-carboxylates by use of copper (I)-catalyzed intramolecular N-arylation has been established. For the preparation of N-monosubstituted and N-unsubstituted derivatives, the cyclization of Boc-protected enehydrazines and subsequent deprotection were applied. Furthermore, 1-alkoxyindole-3- carboxylates can be synthesized by use of the same protocol (© Wiley-VCH Verlag GmbH ...