steroids

Regio-and stereoselective reductions of dehydrocholic acid

G Cravotto, A Binello, L Boffa, O Rosati, M Boccalini…

文献索引：Cravotto, Giancarlo; Binello, Arianna; Boffa, Luisa; Rosati, Ornelio; Boccalini, Marco; Chimichi, Stefano Steroids, 2006 , vol. 71, # 6 p. 469 - 475

全文：HTML全文

被引用次数: 7

摘要

Dehydrocholic acid (DHCA), an unnatural bile acid, is manufactured by oxidation of cholic acid. Its biotransformation by two basidiomycetes (Trametes hirsuta and Collybia velutipes) is reported. These mycelia showed different affinities for the substrate and selectivities of attack: T. hirsuta in particular regio-and stereoselectively reduced the 3-keto group to yield 3α-hydroxy-7, 12-diketo-5β-cholan-24-oic acid (7, 12-diketolithocolic acid) as the main ...