Structure–activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues

…, S Hostyn, L Dhooghe, P Tapolcsányi, P Mátyus…

文献索引：Van Baelen, Gitte; Hostyn, Steven; Dhooghe, Liene; Tapolcsanyi, Pal; Matyus, Peter; Lemiere, Guy; Dommisse, Roger; Kaiser, Marcel; Brun, Reto; Cos, Paul; Maes, Louis; Hajos, Gyoergy; Riedl, Zsuzsanna; Nagy, Ildiko; Maes, Bert U.W.; Pieters, Luc Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 20 p. 7209 - 7217

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被引用次数: 35

摘要

Based on the indoloquinoline alkaloids cryptolepine (1), neocryptolepine (2), isocryptolepine (3) and isoneocryptolepine (4), used as lead compounds for new antimalarial agents, a series of tricyclic and bicyclic analogues, including carbolines, azaindoles, pyrroloquinolines and pyrroloisoquinolines was synthesized and biologically evaluated. None of the bicyclic compounds was significantly active against the ...