Diversity-oriented chemical modification of heparin: Identification of charge-reduced N-acyl heparin derivatives having increased selectivity for heparin-binding …
L Huang, RJ Kerns
文献索引：Huang, Liusheng; Kerns, Robert J. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 7 p. 2300 - 2313
The diversity-oriented chemical modification of heparin is shown to afford charge-reduced heparin derivatives that possess increased selectivity for binding heparin-binding proteins. Variable N-desulfonation of heparin was employed to afford heparin fractions possessing varied levels of free amine. These N-desulfonated heparin fractions were selectively N- acylated with structurally diverse carboxylic acids using a parallel synthesis protocol to ...
