Herbicides play an important role in agricultural practices. In recent 30 years, herbicides targeting the enzyme protoporphyrinogen IX oxidase (Protox), which have been used commercially to control annual grasses and weeds in soybean, peanut, cotton, rice, and other crops, are developed rapidly [1–3], because this type of herbicides shows high bioactivity and low toxicity. Diphenyl ether (DPE) herbicides are the first widely used family ...