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Medicinal Chemistry Research

Synthesis, antitubercular activity, and QSAR analysis of substituted nitroaryl analogs: chalcone, pyrazole, isoxazole, and pyrimidines

RA Gupta, SG Kaskhedikar

文献索引:Gupta, Revathi A.; Kaskhedikar, Satish G. Medicinal Chemistry Research, 2013 , vol. 22, # 8 p. 3863 - 3880

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被引用次数: 15

摘要

Abstract In the present investigation, 4-nitroacetophenone, on condensation with appropriate aldehydes in ethanolic sodium hydroxide solution, yielded the corresponding chalcones. These corresponding chalcones were reacted with hydrazine hydrate, urea, thiourea, and hydroxylamine hydrochloride, which led to the formation of corresponding novel pyrazole, pyrimidine, and isooxazole derivatives, respectively. All newly synthesized ...