New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells

…, E Migianu, A Néguesque, E Battaglia, D Bagrel…

文献索引：Brault, Laurent; Migianu, Evelyne; Neguesque, Adrien; Battaglia, Eric; Bagrel, Denyse; Kirsch, Gilbert European Journal of Medicinal Chemistry, 2005 , vol. 40, # 8 p. 757 - 763

全文：HTML全文

被引用次数: 61

摘要

Thieno analogues of kenpaullone have been synthesized using an established method. We investigated the effect of five structural analogues of kenpaullone on vincristine sensitive and resistant MCF7 (human mammary adenocarcinoma) cells. One analogue, 8-Bromo-6, 11-dihydro-thieno-[3′, 2′: 2, 3] azepino [4, 5-b] indol-5 (4H)-one (3a), showed an antiproliferative activity in the drug sensitive cell line that led to cell accumulation in G2/M ...