Potent, selective, and systemically-available inhibitors of acyl-coenzyme A: cholesterol acyl transferase (ACAT)
…, CA Marzetta, MJ Bamberger, BJ Gaynor…
文献索引：McCarthy, Peter A.; Hamanaka, Ernest S.; Marzetta, Carol A.; Bamberger, Mark J.; Gaynor, B. J.; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1252 - 1255
Acyl-coenzyme Acholesterol acyl transferase (ACAT, EC 2.3. 1.2612 is the enzyme responsible for intracellular esterification of cholesterol? ACAT-mediated cholesterol esterification is believed to play a key role in intestinal absorption of cholesterol, hepatic production of lipoproteins, and the deposition of cholesteryl esters in atherosclerotic lesion^.^ As such, ACAT inhibitors are hypothesized to generate enhanced effects on ...
