Adenosine deaminase inhibitors: synthesis and structure activity relationships of imidazole analogs of erythro-9-(2-hydroxy-3-nonyl) adenine

…, A Eleuteri, P Franchetti, M Grifantini…

文献索引：Cristalli; Eleuteri; Franchetti; Grifantini; Vittori; Lupidi Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1187 - 1192

全文：HTML全文

被引用次数: 24

摘要

A series of erythro-l-(2-hydroxy-3-nonyl) imidazole derivatives have been synthesized and evaluated for adenosine deaminase (ADA) inhibitory activity, in order to introduce simplifications in the ADA inhibitors erythro-942-hydroxy-3-nony1) adenine (EHNA, la) and 3- deaza-EHNA (IC). Opening the pyrimidine or pyridine ring of EHNA or 3-deaza-EHNA respectively led to compounds which are still ADA inhibitors. The most potent compound ...