Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors

SJ Leiris, OM Khdour, ZJ Segerman, KS Tsosie…

文献索引：Leiris, Simon J.; Khdour, Omar M.; Segerman, Zachary J.; Tsosie, Krystal S.; Chapuis, Jean-Charles; Hecht, Sidney M. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 10 p. 3481 - 3493

全文：HTML全文

被引用次数: 11

摘要

Verticipyrone has recently been isolated from the culture broth of Verticillium sp. and shown to inhibit NADH fumarate reductase, as well as NADH oxidoreductase (complex I) of the mitochondrial electron transport chain. In order to assess the structural elements in verticipyrone essential for complex I inhibitor, 15 structural analogues were prepared and analyzed for their effects on mitochondrial NADH oxidoreductase and NADH oxidase ...