N-Alkylated 2, 3, 3-trimethylindolenines and 2-methylbenzothiazoles. Potential lead compounds in the fight against Saccharomyces cerevisiae infections
…, CL Lawrence, VC Jones, C Moffatt, RB Smith
文献索引：Tyler, Andrew R.; Okoh, Adeyi Okoh; Lawrence, Clare L.; Jones, Vicky C.; Moffatt, Colin; Smith, Robert B. European Journal of Medicinal Chemistry, 2013 , vol. 64, p. 222 - 227
The synthesis of a variety of N-alkylated 2, 3, 3-trimethylindolenines and 2- methylbenzothiazoles is reported herein. Their potential as antifungal agents is evaluated by preliminary screening against Saccharomyces cerevisiae (S. cerevisiae), Schizosaccharomyces pombe (S. pombe), and Candida albicans (C. albicans). Statistical analyses illustrate a strong relationship between chain length and growth inhibition for S. ...
