Asymmetric Total Synthesis of (−)??Callystatin A and (−)??20??epi??Callystatin A Employing Chemical and Biological Methods

…, JL Vicario, A Job, M Wolberg…

文献索引：Enders, Dieter; Vicario, Jose L.; Job, Andreas; Wolberg, Michael; Mueller, Michael Chemistry - A European Journal, 2002 , vol. 8, # 18 p. 4272 - 4284

全文：HTML全文

被引用次数: 53

摘要

Abstract An efficient asymmetric total synthesis of the potent cytotoxic marine natural product (−)-callystatin A and its 20-epi analogue has been achieved. The synthetic pathway involved the preparation of three fragments to be coupled with each other at the end of the route. The first fragment 3 was obtained using a biocatalytic enantioselective reduction of a 3, 5- dioxocarboxylate as the key step. For the second intermediate 4 the asymmetric α- ...