[[. omega.-(Heterocyclylamino) alkoxy] benzyl]-2, 4-thiazolidinediones as potent antihyperglycemic agents

BCC Cantello, MA Cawthorne, GP Cottam…

文献索引：Cantello, Barrie C.C.; Cawthorne, Michael A.; Cottam, Graham P.; Duff, Peter T.; Haigh, David; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3977 - 3985

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被引用次数: 225

摘要

benzyl]-2, 4-thiazolidinediones was synthesized from the corresponding aldehydes. Compounds from the urea series, exemplified by 16, showed antihyperglycemic potency comparable with known agents of the type such as pioglitazone and troglitazone (CS-045). The benzoxazole 49, a cyclic analogue of 16, was a very potent enhancer of insulin sensitivity, and by modification of the aromatic heterocycle, an aminopyridine, 37, was ...