Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency

…, KC Ruparelia, A Papakyriakou, H Filippakis…

文献索引：Androutsopoulos, Vasilis P.; Ruparelia, Ketan C.; Papakyriakou, Athanasios; Filippakis, Harilaos; Tsatsakis, Aristeidis M.; Spandidos, Demetrios A. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2586 - 2595

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被引用次数: 33

摘要

Abstract The methoxylated trans-stilbene resveratrol analogue,(E)-3, 4, 5, 4′- tetramethoxystilbene (1), has shown promising antiproliferative activity in in vitro cell line and in vivo models. In vivo1 gives rise to several metabolic products through demethylation or hydroxylation reactions at the stilbene moiety. In the present study we examined the anticancer activity of 1 and the metabolites (E)-3′-hydroxy-3, 4, 5, 4′- ...