Chemistry Letters

Liposomes that can be disintegrated by photo-irradiation.

A Kusumi, S Nakahama, K Yamaguchi

文献索引：Kusumi, Akihiro; Nakahama, Seiichi; Yamaguchi, Kazuo Chemistry Letters, 1989 , p. 433 - 436

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被引用次数: 11

摘要

Photo-labile phosphatidylcholine (PLPC) was synthesized which contains 2-nitrobenzyl esters at the terminals of both alkyl chains. Photolysis of the esters generates carboxylate ions in the hydrophobic region of the PLPC membrane, leading to instant disintegration of PLPC liposomes as observed by the phase contrast microscopy. Upon UV irradiation, entrapped macromolecules (45-kdalton ovalbumin) were released from PLPC liposomes.