Synthesis and structure–activity relationships of dehydroaltenusin derivatives as selective DNA polymerase α inhibitors

…, S Kamisuki, K Tsubaki, F Sugawara, H Yoshida…

文献索引：Kuramochi, Kouji; Fukudome, Keishi; Kuriyama, Isoko; Takeuchi, Toshifumi; Sato, Yoshihiro; Kamisuki, Shinji; Tsubaki, Kazunori; Sugawara, Fumio; Yoshida, Hiromi; Mizushina, Yoshiyuki Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 20 p. 7227 - 7238

全文：HTML全文

被引用次数: 13

摘要

Herein, we describe the synthesis and structure–activity relationships of dehydroaltenusin derivatives as inhibitors of a mammalian DNA polymerase α. We have newly synthesized nine dehydroaltenusin derivatives modified at the side chains or benzoquinone moiety. We also achieved the first synthesis of desmethylaltenusin and desmethyldehydroaltenusin, metabolites of Alternaria sp. or Talaromyces flavus, respectively. Among all synthesized ...