The Journal of organic chemistry

Iodine/palladium approaches to the synthesis of polyheterocyclic compounds

S Mehta, RC Larock

文献索引：Mehta, Saurabh; Larock, Richard C. Journal of Organic Chemistry, 2010 , vol. 75, # 5 p. 1652 - 1658

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被引用次数: 93

摘要

A simple, straightforward strategy for the synthesis of polyheterocyclic compounds (PHCs) is reported, which involves iterative cycles of palladium-catalyzed Sonogashira coupling, followed by iodocyclization using I2 or ICl. A variety of heterocyclic units, including benzofurans, benzothiophenes, indoles, and isocoumarins, can be efficiently incorporated under mild reaction conditions. In addition, variations of this strategy afford a variety of ...