Tetrahedron letters

Zinc-copper (I) chloride or-silver (I) acetate promoted aldol reaction of chlorodifluoromethyl ketones with carbonyl compounds. A general and effective route to α, α- …

M Kuroboshi, T Ishihara

文献索引：Kuroboshi, Manabu; Ishihara, Takashi Tetrahedron Letters, 1987 , vol. 28, # 51 p. 6481 - 6484

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被引用次数: 51

摘要

Abstract Chlorodifluoromethyl ketones efficiently underwent the aldol reaction with a variety of aldehydes or ketones in the presence of zinc, a catalytic amount of copper (I) chloride or silver (I) acetate and molecular sieves to give the corresponding α, α-difluoro-β-hydroxy ketones in good to excellent yields.