Organic letters

Enantioselective synthesis of indolizidines bearing quaternary substituted stereocenters via rhodium-catalyzed [2+ 2+ 2] cycloaddition of alkenyl isocyanates and …

EE Lee, T Rovis

文献索引：Organic Letters, , vol. 10, # 6 p. 1231 - 1234

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被引用次数: 58

摘要

... Volume: Page: ... Organic Letters. ... tests, we were pleased to discover that the methyl-substituted isocyanate 5a (0.12 M in toluene) reacts with phenylacetylene (2 equiv) in the presence of [Rh(C 2 H 4 ) 2 Cl] 2 (5 mol %) and phosphoramidite L3 (10 mol %) to ...