Synthesis of R (+)-α-Lipoic Acid

AV Rama Rao, AV Purandare, ER Reddy…

文献索引：Rao, A.V. Rama; Purandare, Ashok V.; Reddy, E. Rajarathnam; Gurjar, M.K. Synthetic Communications, 1987 , vol. 17, # 9 p. 1095 - 1102

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被引用次数: 13

摘要

The strategy for the synthesis as depicted in Scheme I involves ... Thus, 3,4,6 tri-0-acety ID-glucal (2) obtained f rom D-glucose 6 , ... Compound ,? was deacetylated using catalytic amount of sodium ... C-6 protons in lH NMR. The mass and IR were in agreement with ... 9 Using the procedure of Rasmussen , compound 6 was converted ... THF. The formation of xanthate derivative was evident from its ... IH NMR which showed downfield shift for multiplet of proton at C-7.