Tetrahedron: Asymmetry

Enzyme catalysed asymmetrization of pyridyl substituted 1, 3-propanediols and of the corresponding diacetates

G Guanti, E Narisano, R Riva

文献索引：Guanti, Giuseppe; Narisano, Enrica; Riva, Renata Tetrahedron Asymmetry, 1997 , vol. 8, # 13 p. 2175 - 2187

全文：HTML全文

被引用次数: 14

摘要

2-(4-pyridyl)-and 2-(2-pyridyl)-1, 3-propanediols 1 and 4 were prepared and asymmetrized by enantioselective acetylation in organic solvent catalysed by hydrolytic enzymes, the best being supported pig pancreatic lipase, to give new valuable heterocyclic chiral building blocks. The asymmetrization of diacetate 6, catalysed by pig pancreatic lipase is also described.