High-throughput optimization of Ir-catalyzed C–H borylation: A tutorial for practical applications

SM Preshlock, B Ghaffari, PE Maligres…

文献索引：Preshlock, Sean M.; Ghaffari, Behnaz; Maligres, Peter E.; Krska, Shane W.; Maleczka, Robert E.; Smith, Milton R. Journal of the American Chemical Society, 2013 , vol. 135, # 20 p. 7572 - 7582

全文：HTML全文

被引用次数: 59

摘要

With the aid of high-throughput screening, the efficiency of Ir-catalyzed C–H borylations has been assessed as functions of precatalyst, boron reagent, ligand, order of addition, temperature, solvent, and substrate. This study not only validated some accepted practices but also uncovered unconventional conditions that were key to substrate performance. We anticipate that insights drawn from these findings will be used to design reaction ...