Synthesis, antimicrobial activity and molecular modeling studies of halogenated 4-[1H-imidazol-1-yl (phenyl) methyl]-1, 5-diphenyl-1H-pyrazoles

G Menozzi, L Merello, P Fossa, S Schenone…

文献索引：Menozzi, Giulia; Merello, Luisa; Fossa, Paola; Schenone, Silvia; Ranise, Angelo; Mosti, Luisa; Bondavalli, Francesco; Loddo, Roberta; Murgioni, Chiara; Mascia, Valeria; La Colla, Paolo; Tamburini, Elena Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 20 p. 5465 - 5483

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被引用次数: 73

摘要

During the course of our studies in the azole antifungals area, we synthesized a number of 1, 5-disubstituted 4-[1H-imidazol-1-yl (phenyl) methyl]-1H-pyrazoles, analogues of bifonazole. 1, 5-Diphenyl-1H-pyrazole 3 showed weak antimycotic and antibacterial activities in vitro against Candida albicans, Cryptococcus neoformans and Staphylococcus aureus. In order to increase these properties, given that the halo substitution was found to ...