One??Pot, Solvent??Free Access to Unsymmetrical Ureas by Palladium??Catalysed Reductive Alkylation Using Molecular Hydrogen

T Mohy El Dine, S Chapron, MC Duclos…

文献索引：Mohy El Dine, Tharwat; Chapron, Simon; Duclos, Marie-Christine; Duguet, Nicolas; Popowycz, Florence; Lemaire, Marc European Journal of Organic Chemistry, 2013 , # 24 p. 5445 - 5454

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被引用次数: 6

摘要

Abstract Palladium-catalysed reductive alkylation of monosubstituted ureas has been studied in the presence of aldehydes and using molecular hydrogen as a clean reductant. Unsymmetrical N, N′-disubstituted ureas were formed in good to excellent isolated yields (60–93%) without the production of salt waste. This reaction was incorporated to a one-pot, solvent-free sequence involving the alkylation of monosubstituted ureas generated in situ ...