In our search for novel anti-HIV agents, seven 17-carboxylated steroid derivatives were synthesized and evaluated as potential anti-HIV agents. Compound 13 exhibited potent anti- HIV activity in acutely infected H9 lymphocytes with EC50 and therapeutic index values of 0.8 μM and 300, respectively.
![(3S,3aS,5aS,6R,9aS,9bS)-6-(2-Carboxyethyl)-3a,6-dimethyl-7-oxodod ecahydro-1H-cyclopenta[a]naphthalene-3-carboxylic acid结构式](https://image.chemsrc.com/caspic/087/76763-14-9.png)
