Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library

…, JJ Deadman, C Furman, R Mansouri, P Chavatte…

文献索引：Spencer, John; Patel, Hiren; Amin, Jahangir; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.; Furman, Christophe; Mansouri, Roxane; Chavatte, Philippe; Millet, Regis Tetrahedron Letters, 2012 , vol. 53, # 13 p. 1656 - 1659

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被引用次数: 12

摘要

A 2-substituted-5-aminooxazole-4-carbonitrile library has been synthesised and modified via microwave-mediated and flow chemistries. One synthesised compound, 5-(1H-pyrrol-1- yl)-4-(1H-tetrazol-5-yl)-2-(thien-2-yl) oxazole, contains three distinct heterocycles attached to the central oxazole core, highlighting the structural diversity of this approach. Three oxazoles had micromolar ki values against cannabinoid (CB1/CB2) receptors.