Design, Synthesis, and Structure− Activity Relationship Studies of Novel 2, 4, 6-Trisubstituted-5-pyrimidinecarboxylic Acids as Peroxisome Proliferator-Activated …

…, T Shinozaki, Y Kitamura, Y Kohno…

文献索引：Seto, Shigeki; Kohno, Yasushi Heterocycles, 2009 , vol. 78, # 9 p. 2263 - 2275

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被引用次数: 13

摘要

A series of novel 2, 4, 6-trisubstitutedpyrimidine-5-carboxylic acid derivatives were designed and synthesized with the intent of producing a peroxisome proliferator-activated receptor γ (PPARγ) partial agonist for antidiabetic agents. A pharmacophore-driven approach of in-