Synthesis and modulation properties of imidazo [4, 5-b] pyridin-7-one and indazole-4, 7-dione derivatives towards the Cryptosporidium parvum CpABC3 transporter

…, S Radix, C Marminon, P Nebois, N Walchshofer

文献索引：Zeinyeh, Wael; Xia, Hexue; Lawton, Philippe; Radix, Sylvie; Marminon, Christelle; Nebois, Pascal; Walchshofer, Nadia European Journal of Medicinal Chemistry, 2010 , vol. 45, # 6 p. 2480 - 2488

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被引用次数: 5

摘要

The syntheses of new N-polysubstituted imidazo [4, 5-b] pyridine-7-one (IP, 5 and 8a–8f) and indazole-4, 7-dione (ID, 9 and 10) derivatives are described. The binding affinity of IP and ID towards the recombinant Nucleotide Binding Domain NBD1 of Cryptosporidium parvum CpABC3 was evaluated by intrinsic fluorescence quenching. IP induced a moderate quenching of the intrinsic fluorescence of H6-NBD1 whereas IDs 9 and 10 showed a ...